Review





Similar Products

cst 4904s anti stat1  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc cst 4904s anti stat1
Cst 4904s Anti Stat1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/Stat3+Rabbit+mAb/pm42875499-768-407-407
Average 96 stars, based on 1 article reviews
cst 4904s anti stat1 - by Bioz Stars, 2026-10
96/100 stars
  Buy from Supplier
cst 9167s anti stat3  (Cell Signaling Technology Inc)
97
Cell Signaling Technology Inc cst 9167s anti stat3
Cst 9167s Anti Stat3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/Phospho-Stat1+(Tyr701)+Rabbit+mAb/pm42875499-768-403-403
Average 97 stars, based on 1 article reviews
cst 9167s anti stat3 - by Bioz Stars, 2026-10
97/100 stars
  Buy from Supplier
cst 9172s anti gapdh  (Cell Signaling Technology Inc)
97
Cell Signaling Technology Inc cst 9172s anti gapdh
Cst 9172s Anti Gapdh, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/Stat1+Antibody/pm42875499-768-411-411
Average 97 stars, based on 1 article reviews
cst 9172s anti gapdh - by Bioz Stars, 2026-10
97/100 stars
  Buy from Supplier
cst 9145s anti phospho stat1  (Cell Signaling Technology Inc)
98
Cell Signaling Technology Inc cst 9145s anti phospho stat1
Cst 9145s Anti Phospho Stat1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/Phospho-Stat3+(Tyr705)+XP+Rabbit+mAb/pm42875499-768-398-398
Average 98 stars, based on 1 article reviews
cst 9145s anti phospho stat1 - by Bioz Stars, 2026-10
98/100 stars
  Buy from Supplier
stat1 inhibitor fludarabine  (MedChemExpress)
97
MedChemExpress stat1 inhibitor fludarabine
Lipid‐free ApoE4 polarizes microglia to interferon and pattern recognition signaling and away from proteostasis programs. (A) PLS‐DA plot of LF‐E4 versus rHDL‐E4 treatment at 24‐h time point. (B) VIP score table displaying top 25 proteins driving differences in PLS‐DA plot. (C) Volcano plot displaying LF‐E4 versus rHDL‐E4, with x ‐axis representing log 2 FC and y ‐axis representing −log 10 ( p value). Purple indicates downregulated proteins in response to LF‐E4 treatment, while orange indicates upregulated proteins in response to LF‐E4 treatment, at 24 h. (D) Heatmap of top 50 DAP in 24‐h group. The color gradient is associated with the normalized concentration. (E) Upregulated biological pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment upregulated in LF‐E4) at 24 h. (F) Upregulated KEGG pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment (upregulated in LF‐E4) at 24 h. (G) Relative gene expression of <t>STAT1</t> and SP100. (H) Venn diagram of overlapping DAPs between LF‐E3 versus rHDL‐E3 treatment compared to LF‐E4 versus rHDL‐E4 treatment. (I) Heatmap of proteins of interest. Columns represent comparisons between groups at 6‐ and 24‐h time points. Rows indicate proteins categorized by function. Color scale indicates fold enrichment representing left versus right group's downregulation shown by a purple gradient and upregulation by an orange gradient. Data are mean ± SEM, n = 3, **p < 0.001, ****p < 0.0001.
Stat1 Inhibitor Fludarabine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/Fludarabine/pmc13655218-98-8-11
Average 97 stars, based on 1 article reviews
stat1 inhibitor fludarabine - by Bioz Stars, 2026-10
97/100 stars
  Buy from Supplier
stat1 rabbit mab  (Selleck Chemicals)
96
Selleck Chemicals stat1 rabbit mab
Lipid‐free ApoE4 polarizes microglia to interferon and pattern recognition signaling and away from proteostasis programs. (A) PLS‐DA plot of LF‐E4 versus rHDL‐E4 treatment at 24‐h time point. (B) VIP score table displaying top 25 proteins driving differences in PLS‐DA plot. (C) Volcano plot displaying LF‐E4 versus rHDL‐E4, with x ‐axis representing log 2 FC and y ‐axis representing −log 10 ( p value). Purple indicates downregulated proteins in response to LF‐E4 treatment, while orange indicates upregulated proteins in response to LF‐E4 treatment, at 24 h. (D) Heatmap of top 50 DAP in 24‐h group. The color gradient is associated with the normalized concentration. (E) Upregulated biological pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment upregulated in LF‐E4) at 24 h. (F) Upregulated KEGG pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment (upregulated in LF‐E4) at 24 h. (G) Relative gene expression of <t>STAT1</t> and SP100. (H) Venn diagram of overlapping DAPs between LF‐E3 versus rHDL‐E3 treatment compared to LF‐E4 versus rHDL‐E4 treatment. (I) Heatmap of proteins of interest. Columns represent comparisons between groups at 6‐ and 24‐h time points. Rows indicate proteins categorized by function. Color scale indicates fold enrichment representing left versus right group's downregulation shown by a purple gradient and upregulation by an orange gradient. Data are mean ± SEM, n = 3, **p < 0.001, ****p < 0.0001.
Stat1 Rabbit Mab, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/Z-VAD-FMK/pm42854924-64-0-11
Average 96 stars, based on 1 article reviews
stat1 rabbit mab - by Bioz Stars, 2026-10
96/100 stars
  Buy from Supplier
stat1  (Cell Signaling Technology Inc)
97
Cell Signaling Technology Inc stat1
Lipid‐free ApoE4 polarizes microglia to interferon and pattern recognition signaling and away from proteostasis programs. (A) PLS‐DA plot of LF‐E4 versus rHDL‐E4 treatment at 24‐h time point. (B) VIP score table displaying top 25 proteins driving differences in PLS‐DA plot. (C) Volcano plot displaying LF‐E4 versus rHDL‐E4, with x ‐axis representing log 2 FC and y ‐axis representing −log 10 ( p value). Purple indicates downregulated proteins in response to LF‐E4 treatment, while orange indicates upregulated proteins in response to LF‐E4 treatment, at 24 h. (D) Heatmap of top 50 DAP in 24‐h group. The color gradient is associated with the normalized concentration. (E) Upregulated biological pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment upregulated in LF‐E4) at 24 h. (F) Upregulated KEGG pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment (upregulated in LF‐E4) at 24 h. (G) Relative gene expression of <t>STAT1</t> and SP100. (H) Venn diagram of overlapping DAPs between LF‐E3 versus rHDL‐E3 treatment compared to LF‐E4 versus rHDL‐E4 treatment. (I) Heatmap of proteins of interest. Columns represent comparisons between groups at 6‐ and 24‐h time points. Rows indicate proteins categorized by function. Color scale indicates fold enrichment representing left versus right group's downregulation shown by a purple gradient and upregulation by an orange gradient. Data are mean ± SEM, n = 3, **p < 0.001, ****p < 0.0001.
Stat1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/Stat1+Rabbit+mAb/pm42849824-144-10-11
Average 97 stars, based on 1 article reviews
stat1 - by Bioz Stars, 2026-10
97/100 stars
  Buy from Supplier
stat1 d1k9y rabbit mab  (Cell Signaling Technology Inc)
99
Cell Signaling Technology Inc stat1 d1k9y rabbit mab
Lipid‐free ApoE4 polarizes microglia to interferon and pattern recognition signaling and away from proteostasis programs. (A) PLS‐DA plot of LF‐E4 versus rHDL‐E4 treatment at 24‐h time point. (B) VIP score table displaying top 25 proteins driving differences in PLS‐DA plot. (C) Volcano plot displaying LF‐E4 versus rHDL‐E4, with x ‐axis representing log 2 FC and y ‐axis representing −log 10 ( p value). Purple indicates downregulated proteins in response to LF‐E4 treatment, while orange indicates upregulated proteins in response to LF‐E4 treatment, at 24 h. (D) Heatmap of top 50 DAP in 24‐h group. The color gradient is associated with the normalized concentration. (E) Upregulated biological pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment upregulated in LF‐E4) at 24 h. (F) Upregulated KEGG pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment (upregulated in LF‐E4) at 24 h. (G) Relative gene expression of <t>STAT1</t> and SP100. (H) Venn diagram of overlapping DAPs between LF‐E3 versus rHDL‐E3 treatment compared to LF‐E4 versus rHDL‐E4 treatment. (I) Heatmap of proteins of interest. Columns represent comparisons between groups at 6‐ and 24‐h time points. Rows indicate proteins categorized by function. Color scale indicates fold enrichment representing left versus right group's downregulation shown by a purple gradient and upregulation by an orange gradient. Data are mean ± SEM, n = 3, **p < 0.001, ****p < 0.0001.
Stat1 D1k9y Rabbit Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/GAPDH+Rabbit+mAb/pm42834039-574-60-64
Average 99 stars, based on 1 article reviews
stat1 d1k9y rabbit mab - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier
anti stat1  (ABclonal Biotechnology)
95
ABclonal Biotechnology anti stat1
Lipid‐free ApoE4 polarizes microglia to interferon and pattern recognition signaling and away from proteostasis programs. (A) PLS‐DA plot of LF‐E4 versus rHDL‐E4 treatment at 24‐h time point. (B) VIP score table displaying top 25 proteins driving differences in PLS‐DA plot. (C) Volcano plot displaying LF‐E4 versus rHDL‐E4, with x ‐axis representing log 2 FC and y ‐axis representing −log 10 ( p value). Purple indicates downregulated proteins in response to LF‐E4 treatment, while orange indicates upregulated proteins in response to LF‐E4 treatment, at 24 h. (D) Heatmap of top 50 DAP in 24‐h group. The color gradient is associated with the normalized concentration. (E) Upregulated biological pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment upregulated in LF‐E4) at 24 h. (F) Upregulated KEGG pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment (upregulated in LF‐E4) at 24 h. (G) Relative gene expression of <t>STAT1</t> and SP100. (H) Venn diagram of overlapping DAPs between LF‐E3 versus rHDL‐E3 treatment compared to LF‐E4 versus rHDL‐E4 treatment. (I) Heatmap of proteins of interest. Columns represent comparisons between groups at 6‐ and 24‐h time points. Rows indicate proteins categorized by function. Color scale indicates fold enrichment representing left versus right group's downregulation shown by a purple gradient and upregulation by an orange gradient. Data are mean ± SEM, n = 3, **p < 0.001, ****p < 0.0001.
Anti Stat1, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat1/STAT1+Rabbit+mAb/pm42829916-401-42-48
Average 95 stars, based on 1 article reviews
anti stat1 - by Bioz Stars, 2026-10
95/100 stars
  Buy from Supplier

Image Search Results


Lipid‐free ApoE4 polarizes microglia to interferon and pattern recognition signaling and away from proteostasis programs. (A) PLS‐DA plot of LF‐E4 versus rHDL‐E4 treatment at 24‐h time point. (B) VIP score table displaying top 25 proteins driving differences in PLS‐DA plot. (C) Volcano plot displaying LF‐E4 versus rHDL‐E4, with x ‐axis representing log 2 FC and y ‐axis representing −log 10 ( p value). Purple indicates downregulated proteins in response to LF‐E4 treatment, while orange indicates upregulated proteins in response to LF‐E4 treatment, at 24 h. (D) Heatmap of top 50 DAP in 24‐h group. The color gradient is associated with the normalized concentration. (E) Upregulated biological pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment upregulated in LF‐E4) at 24 h. (F) Upregulated KEGG pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment (upregulated in LF‐E4) at 24 h. (G) Relative gene expression of STAT1 and SP100. (H) Venn diagram of overlapping DAPs between LF‐E3 versus rHDL‐E3 treatment compared to LF‐E4 versus rHDL‐E4 treatment. (I) Heatmap of proteins of interest. Columns represent comparisons between groups at 6‐ and 24‐h time points. Rows indicate proteins categorized by function. Color scale indicates fold enrichment representing left versus right group's downregulation shown by a purple gradient and upregulation by an orange gradient. Data are mean ± SEM, n = 3, **p < 0.001, ****p < 0.0001.

Journal: Alzheimer's & Dementia

Article Title: ApoE lipidation state directs immunometabolic reprogramming of human microglia

doi: 10.1002/alz.71882

Figure Lengend Snippet: Lipid‐free ApoE4 polarizes microglia to interferon and pattern recognition signaling and away from proteostasis programs. (A) PLS‐DA plot of LF‐E4 versus rHDL‐E4 treatment at 24‐h time point. (B) VIP score table displaying top 25 proteins driving differences in PLS‐DA plot. (C) Volcano plot displaying LF‐E4 versus rHDL‐E4, with x ‐axis representing log 2 FC and y ‐axis representing −log 10 ( p value). Purple indicates downregulated proteins in response to LF‐E4 treatment, while orange indicates upregulated proteins in response to LF‐E4 treatment, at 24 h. (D) Heatmap of top 50 DAP in 24‐h group. The color gradient is associated with the normalized concentration. (E) Upregulated biological pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment upregulated in LF‐E4) at 24 h. (F) Upregulated KEGG pathway analysis of DAPs in response to LF‐E4 versus rHDL‐E4 treatment (upregulated in LF‐E4) at 24 h. (G) Relative gene expression of STAT1 and SP100. (H) Venn diagram of overlapping DAPs between LF‐E3 versus rHDL‐E3 treatment compared to LF‐E4 versus rHDL‐E4 treatment. (I) Heatmap of proteins of interest. Columns represent comparisons between groups at 6‐ and 24‐h time points. Rows indicate proteins categorized by function. Color scale indicates fold enrichment representing left versus right group's downregulation shown by a purple gradient and upregulation by an orange gradient. Data are mean ± SEM, n = 3, **p < 0.001, ****p < 0.0001.

Article Snippet: A subset of cells was treated with the STAT1 inhibitor Fludarabine (MedChemExpress, Catalog No.: HY‐B0069) at the same time as LF‐ApoE4 (LF‐E4).

Techniques: Concentration Assay, Analysis, Gene Expression